Syk Activation in Dendritic Cells Is Essential for Airway Hyperresponsiveness and Inflammation

We evaluated the role of Syk, using an inhibitor, on allergen-induced airway hyperresponsiveness (AHR) and airway inflammation in a system shown to be B cell– and mast cell–independent. Sensitization of BALB/c mice with ovalbumin (OVA) and alum after three consecutive OVA challenges resulted in AHR...

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Auteurs principaux: Matsubara, Shigeki, Koya, Toshiyuki, Takeda, Katsuyuki, Joetham, Anthony, Miyahara, Nobuaki, Pine, Polly, Masuda, Esteban S., Swasey, Christina H., Gelfand, Erwin W.
Format: Artigo
Langue:Inglês
Publié: American Thoracic Society 2006
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644204/
https://ncbi.nlm.nih.gov/pubmed/16339999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2005-0298OC
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