Inhibition of Spleen Tyrosine Kinase Prevents Mast Cell Activation and Airway Hyperresponsiveness

Rationale: Spleen tyrosine kinase (Syk) is important for Fc and B-cell receptor–mediated signaling. Objective: To determine the activity of a specific Syk inhibitor (R406) on mast cell activation in vitro and on the development of allergen-induced airway hyperresponsiveness (AHR) and inflammation in...

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Detalhes bibliográficos
Main Authors: Matsubara, Shigeki, Li, Guiming, Takeda, Katsuyuki, Loader, Joan E., Pine, Polly, Masuda, Esteban S., Miyahara, Nobuaki, Miyahara, Satoko, Lucas, Joseph J., Dakhama, Azzeddine, Gelfand, Erwin W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2006
Assuntos:
B. Asthma and Allergy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662982/
https://ncbi.nlm.nih.gov/pubmed/16192454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200503-361OC
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