A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore

As the need for novel antibiotic classes to combat bacterial drug resistance increases, the paucity of leads resulting from target-based antibacterial screening of pharmaceutical compound libraries is of major concern. One explanation for this lack of success is that antibacterial screening efforts...

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Main Authors: Miller, J. Richard, Dunham, Steve, Mochalkin, Igor, Banotai, Craig, Bowman, Matthew, Buist, Susan, Dunkle, Bill, Hanna, Debra, Harwood, H. James, Huband, Michael D., Karnovsky, Alla, Kuhn, Michael, Limberakis, Chris, Liu, Jia Y., Mehrens, Shawn, Mueller, W. Thomas, Narasimhan, Lakshmi, Ogden, Adam, Ohren, Jeff, Prasad, J. V. N. Vara, Shelly, John A., Skerlos, Laura, Sulavik, Mark, Thomas, V. Hayden, VanderRoest, Steve, Wang, LiAnn, Wang, Zhigang, Whitton, Amy, Zhu, Tong, Stover, C. Kendall
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644107/
https://ncbi.nlm.nih.gov/pubmed/19164768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811275106
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