Characterization of substrate binding and catalysis in the potential antibacterial target N-acetylglucosamine-1-phosphate uridyltransferase (GlmU)

N-Acetylglucosamine-1-phosphate uridyltransferase (GlmU) catalyzes the first step in peptidoglycan biosynthesis in both Gram-positive and Gram-negative bacteria. The products of the GlmU reaction are essential for bacterial survival, making this enzyme an attractive target for antibiotic drug discov...

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Main Authors: Mochalkin, Igor, Lightle, Sandra, Zhu, Yaqi, Ohren, Jeffrey F., Spessard, Cindy, Chirgadze, Nickolay Y., Banotai, Craig, Melnick, Michael, McDowell, Laura
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2222810/
https://ncbi.nlm.nih.gov/pubmed/18029420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073135107
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