Structure of a small-molecule inhibitor complexed with GlmU from Haemophilus influenzae reveals an allosteric binding site

N-Acetylglucosamine-1-phosphate uridyltransferase (GlmU) is an essential enzyme in aminosugars metabolism and an attractive target for antibiotic drug discovery. GlmU catalyzes the formation of uridine-diphospho-N-acetylglucosamine (UDP-GlcNAc), an important precursor in the peptidoglycan and lipopo...

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Main Authors: Mochalkin, Igor, Lightle, Sandra, Narasimhan, Lakshmi, Bornemeier, Dirk, Melnick, Michael, VanderRoest, Steven, McDowell, Laura
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Protein Structure Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248321/
https://ncbi.nlm.nih.gov/pubmed/18218712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073271408
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