A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore

As the need for novel antibiotic classes to combat bacterial drug resistance increases, the paucity of leads resulting from target-based antibacterial screening of pharmaceutical compound libraries is of major concern. One explanation for this lack of success is that antibacterial screening efforts...

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Autores principales: Miller, J. Richard, Dunham, Steve, Mochalkin, Igor, Banotai, Craig, Bowman, Matthew, Buist, Susan, Dunkle, Bill, Hanna, Debra, Harwood, H. James, Huband, Michael D., Karnovsky, Alla, Kuhn, Michael, Limberakis, Chris, Liu, Jia Y., Mehrens, Shawn, Mueller, W. Thomas, Narasimhan, Lakshmi, Ogden, Adam, Ohren, Jeff, Prasad, J. V. N. Vara, Shelly, John A., Skerlos, Laura, Sulavik, Mark, Thomas, V. Hayden, VanderRoest, Steve, Wang, LiAnn, Wang, Zhigang, Whitton, Amy, Zhu, Tong, Stover, C. Kendall
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2009
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644107/
https://ncbi.nlm.nih.gov/pubmed/19164768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811275106
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