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CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure
The CXCR4/SDF-1 axis has been studied extensively because of its role in development and hematopoiesis. In acute myeloid leukemia (AML), elevated expression of CXCR4 has been shown to correlate with shortened survival. Hy-poxia increases CXCR4 in several tumor models, but the impact of reduced O(2)...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society of Hematology
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2644078/ https://ncbi.nlm.nih.gov/pubmed/18957686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-06-161539 |
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