BLNK suppresses pre–B-cell leukemogenesis through inhibition of JAK3

Pre–B-cell leukemia spontaneously develops in BLNK-deficient mice, and pre–B-cell acute lymphoblastic leukemia cells in children often lack BLNK protein expression, demonstrating that BLNK functions as a tumor suppressor. However, the mechanism by which BLNK suppresses pre–B-cell leukemia, as well a...

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Hlavní autoři: Nakayama, Joji, Yamamoto, Mutsumi, Hayashi, Katsuhiko, Satoh, Hitoshi, Bundo, Kenji, Kubo, Masato, Goitsuka, Ryo, Farrar, Michael A., Kitamura, Daisuke
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2009
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644075/
https://ncbi.nlm.nih.gov/pubmed/19047679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-07-166355
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