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Loss of p21(Waf1/Cip1/Sdi1) enhances intestinal stem cell survival following radiation injury
The microcolony assay following gamma irradiation (IR) is a functional assay of intestinal stem cell fate. The cyclin-dependent kinase (CDK) inhibitor p21(Waf1/Cip1/Sdi1) (p21) regulates cell cycle arrest following DNA damage. To explore the role of p21 on stem cell fate, we examined the effects of...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Physiological Society
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2643902/ https://ncbi.nlm.nih.gov/pubmed/19056768 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00021.2008 |
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