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p21(WAF1/Cip1/Sdi1) Knockout Mice Respond to Doxorubicin with Reduced Cardiotoxicity
Doxorubicin (Dox) is an antineoplastic agent that can cause cardiomyopathy in humans and experimental animals. As an inducer of reactive oxygen species and a DNA damaging agent, Dox causes elevated expression of p21(WAF1/Cip1/Sdi1) (p21) gene. Elevated levels of p21 mRNA and p21 protein have been de...
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| Main Authors: | , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2011
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4129958/ https://ncbi.nlm.nih.gov/pubmed/21920376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2011.08.024 |
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