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p21(WAF1/Cip1/Sdi1) Knockout Mice Respond to Doxorubicin with Reduced Cardiotoxicity

Doxorubicin (Dox) is an antineoplastic agent that can cause cardiomyopathy in humans and experimental animals. As an inducer of reactive oxygen species and a DNA damaging agent, Dox causes elevated expression of p21(WAF1/Cip1/Sdi1) (p21) gene. Elevated levels of p21 mRNA and p21 protein have been de...

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Bibliografiska uppgifter
Huvudupphovsmän: Terrand, Jerome, Xu, Beibei, Morrissy, Steve, Dinh, Thai Nho, Williams, Stuart, Chen, Qin M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4129958/
https://ncbi.nlm.nih.gov/pubmed/21920376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2011.08.024
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