Loss of p21(Waf1/Cip1/Sdi1) enhances intestinal stem cell survival following radiation injury

The microcolony assay following gamma irradiation (IR) is a functional assay of intestinal stem cell fate. The cyclin-dependent kinase (CDK) inhibitor p21(Waf1/Cip1/Sdi1) (p21) regulates cell cycle arrest following DNA damage. To explore the role of p21 on stem cell fate, we examined the effects of...

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Hlavní autoři: George, Robert J., Sturmoski, Mark A., May, Randal, Sureban, Sripathi M., Dieckgraefe, Brian K., Anant, Shrikant, Houchen, Courtney W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2009
Témata:
Mucosal Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643902/
https://ncbi.nlm.nih.gov/pubmed/19056768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00021.2008
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