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PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns

Platelet-derived growth factor (PDGF)-BB is a well-known smooth muscle (SM) cell (SMC) phenotypic modulator that signals by binding to PDGF αα-, αβ-, and ββ-membrane receptors. PDGF-DD is a recently identified PDGF family member, and its role in SMC phenotypic modulation is unknown. Here we demonstr...

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Autors principals: Thomas, James A., Deaton, Rebecca A., Hastings, Nicole E., Shang, Yueting, Moehle, Christopher W., Eriksson, Ulf, Topouzis, Stavros, Wamhoff, Brian R., Blackman, Brett R., Owens, Gary K.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643880/
https://ncbi.nlm.nih.gov/pubmed/19028801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00165.2008
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