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DNA Genome Size Affects the Stability of the Adenovirus Virion

Replication-defective adenovirus (Ad) vectors can vary considerably in genome length, but whether this affects virion stability has not been investigated. Helper-dependent Ad vectors with a genome size of ∼30 kb were 100-fold more sensitive to heat inactivation than their parental helper virus (>...

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Detalhes bibliográficos
Main Authors: Smith, Adam C., Poulin, Kathy L., Parks, Robin J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643769/
https://ncbi.nlm.nih.gov/pubmed/19036812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01644-08
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