An Engineered Human Antibody Fab Fragment Specific for Pseudomonas aeruginosa PcrV Antigen Has Potent Antibacterial Activity

Pseudomonas aeruginosa is an opportunistic pathogen that can cause acute lung injury and mortality through the delivery of exotoxins by the type III secretion system (TTSS). PcrV is an important structural protein of the TTSS. An engineered human antibody Fab fragment that binds to the P. aeruginosa...

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Detalhes bibliográficos
Main Authors: Baer, Mark, Sawa, Teiji, Flynn, Peter, Luehrsen, Kenneth, Martinez, David, Wiener-Kronish, Jeanine P., Yarranton, Geoffrey, Bebbington, Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643635/
https://ncbi.nlm.nih.gov/pubmed/19103766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00815-08
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