Tiam1 and Rac1 Are Required for Platelet-activating Factor-induced Endothelial Junctional Disassembly and Increase in Vascular Permeability

It is known that platelet-activating factor (PAF) induces severe endothelial barrier leakiness, but the signaling mechanisms remain unclear. Here, using a wide range of biochemical and morphological approaches applied in both mouse models and cultured endothelial cells, we addressed the mechanisms o...

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Main Authors: Knezevic, Ivana I., Predescu, Sanda A., Neamu, Radu F., Gorovoy, Matvey S., Knezevic, Nebojsa M., Easington, Cordus, Malik, Asrar B., Predescu, Dan N.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643508/
https://ncbi.nlm.nih.gov/pubmed/19095647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808958200
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