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Mechanism of Action of Cyclophilin A Explored by Metadynamics Simulations
Trans/cis prolyl isomerisation is involved in several biological processes, including the development of numerous diseases. In the HIV-1 capsid protein (CA), such a process takes place in the uncoating and recruitment of the virion and is catalyzed by cyclophilin A (CypA). Here, we use metadynamics...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2643488/ https://ncbi.nlm.nih.gov/pubmed/19282959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000309 |
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