Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides

Endomorphin 1 (Endo-1 = Tyr-Pro-Trp-Phe-NH(2)), an endogenous opioid with high affinity and selectivity for μ-opioid receptors, mediates acute and neuropathic pain in rodents. To overcome metabolic instability and poor membrane permeability, the N- and C-termini of Endo-1 were modified by lipoamino...

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Bibliografiske detaljer
Main Authors: Koda, Yasuko, Borgo, Mark Del, Wessling, Susanne T., Lazarus, Lawrence H., Okada, Yoshio, Toth, Istvan, Blanchfield, Joanne T.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643467/
https://ncbi.nlm.nih.gov/pubmed/18468445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.04.020
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