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Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides
Endomorphin 1 (Endo-1 = Tyr-Pro-Trp-Phe-NH(2)), an endogenous opioid with high affinity and selectivity for μ-opioid receptors, mediates acute and neuropathic pain in rodents. To overcome metabolic instability and poor membrane permeability, the N- and C-termini of Endo-1 were modified by lipoamino...
Tallennettuna:
| Päätekijät: | , , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2008
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2643467/ https://ncbi.nlm.nih.gov/pubmed/18468445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.04.020 |
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