Increased thymus- and decreased parathyroid-fated organ domains in Splotch mutant embryos

Embryos that are homozygous for Splotch, a null allele of Pax3, have a severe neural crest cell (NCC) deficiency that generates a complex phenotype including spina bifida, exencephaly and cardiac outflow tract abnormalities. Contrary to the widely held perception that thymus aplasia or hypoplasia is...

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Autori principali: Griffith, Ann V., Cardenas, Kim, Carter, Carla, Gordon, Julie, Iberg, Aimee, Engleka, Kurt, Epstein, Jonathan A., Manley, Nancy R., Richie, Ellen R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643307/
https://ncbi.nlm.nih.gov/pubmed/19135046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2008.12.019
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