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Tissue-specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate

The thymus and parathyroids develop from third pharyngeal pouch (3rd pp) endoderm. Our previous studies show that Shh null mice have smaller, aparathyroid primordia in which thymus fate specification extends into the pharynx. SHH signaling is active in both dorsal pouch endoderm and neighboring neur...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Bain, Virginia E., Gordon, Julie, O'Neil, John D., Ramos, Isaias, Richie, Ellen R., Manley, Nancy R.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117149/
https://ncbi.nlm.nih.gov/pubmed/27633995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.141903
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