Tissue-specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate

The thymus and parathyroids develop from third pharyngeal pouch (3rd pp) endoderm. Our previous studies show that Shh null mice have smaller, aparathyroid primordia in which thymus fate specification extends into the pharynx. SHH signaling is active in both dorsal pouch endoderm and neighboring neur...

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Bibliographic Details
Published in:Development
Main Authors: Bain, Virginia E., Gordon, Julie, O'Neil, John D., Ramos, Isaias, Richie, Ellen R., Manley, Nancy R.
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117149/
https://ncbi.nlm.nih.gov/pubmed/27633995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.141903
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