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Heterogeneity of large macromolecular complexes revealed by 3-D cryo-EM variance analysis
Macromolecular structure determination by cryo-electron microscopy (EM) and single particle analysis are based on the assumption that imaged molecules have identical structure. With the increased size of processed datasets it becomes apparent that many complexes coexist in a mixture of conformationa...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2642923/ https://ncbi.nlm.nih.gov/pubmed/19081053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.10.011 |
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