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Identifying conformational states of macromolecules by eigen-analysis of resampled cryo-EM images
We present the codimensional PCA, a novel and straightforward method for resolving sample heterogeneity within a set of cryo-EM 2D projection images of macromolecular assemblies. The method employs Principal Component Analysis (PCA) of resmapled 3D structures computed using subsets of 2D data obtain...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3255080/ https://ncbi.nlm.nih.gov/pubmed/22078558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.10.003 |
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