Alterations in Genes of the EGFR Signaling Pathway and Their Relationship to EGFR Tyrosine Kinase Inhibitor Sensitivity in Lung Cancer Cell Lines

BACKGROUND: Deregulation of EGFR signaling is common in non-small cell lung cancers (NSCLC) and this finding led to the development of tyrosine kinase inhibitors (TKIs) that are highly effective in a subset of NSCLC. Mutations of EGFR (mEGFR) and copy number gains (CNGs) of EGFR (gEGFR) and HER2 (gH...

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Autores principales: Gandhi, Jeet, Zhang, Jianling, Xie, Yang, Soh, Junichi, Shigematsu, Hisayuki, Zhang, Wei, Yamamoto, Hiromasa, Peyton, Michael, Girard, Luc, Lockwood, William W., Lam, Wan L., Varella-Garcia, Marileila, Minna, John D., Gazdar, Adi F.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2009
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2642732/
https://ncbi.nlm.nih.gov/pubmed/19238210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004576
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