Genetic Variation in OAS1 Is a Risk Factor for Initial Infection with West Nile Virus in Man

West Nile virus (WNV) is a re-emerging pathogen that can cause fatal encephalitis. In mice, susceptibility to WNV has been reported to result from a single point mutation in oas1b, which encodes 2′–5′ oligoadenylate synthetase 1b, a member of the type I interferon-regulated OAS gene family involved...

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Autori principali: Lim, Jean K., Lisco, Andrea, McDermott, David H., Huynh, Linda, Ward, Jerrold M., Johnson, Bernard, Johnson, Hope, Pape, John, Foster, Gregory A., Krysztof, David, Follmann, Dean, Stramer, Susan L., Margolis, Leonid B., Murphy, Philip M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2642680/
https://ncbi.nlm.nih.gov/pubmed/19247438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000321
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