CCR5 Deficiency is a Risk Factor for Early Clinical Manifestations of West Nile Virus Infection, but not for Infection per se

BACKGROUND: West Nile virus (WNV) is a neurotropic flavivirus transmitted to humans by mosquito vectors. Homozygosity for CCR5Δ32, a complete loss-of-function mutation in the chemokine receptor CCR5, has been previously associated with severe symptomatic WNV infection in patients presenting with cli...

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Main Authors: Lim, Jean K., McDermott, David H., Lisco, Andrea, Foster, Gregory A., Krysztof, David, Follmann, Dean, Stramer, Susan L., Murphy, Philip M.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934858/
https://ncbi.nlm.nih.gov/pubmed/20025530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/649426
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