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The Immunophilin Ligands Cyclosporin A and FK506 Suppress Prostate Cancer Cell Growth by Androgen Receptor-Dependent and -Independent Mechanisms
Androgen receptor (AR) contributes to growth of prostate cancer even under conditions of androgen ablation. Thus, new strategies to target AR activity are needed. AR interacts with the immunophilin FK506-binding protein 52 (FKBP52), and studies in the FKBP52 KO mouse have shown this protein is essen...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2639775/ https://ncbi.nlm.nih.gov/pubmed/17615153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2007-0145 |
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