The D4Z4 Macrosatellite Repeat Acts as a CTCF and A-Type Lamins-Dependent Insulator in Facio-Scapulo-Humeral Dystrophy

Both genetic and epigenetic alterations contribute to Facio-Scapulo-Humeral Dystrophy (FSHD), which is linked to the shortening of the array of D4Z4 repeats at the 4q35 locus. The consequence of this rearrangement remains enigmatic, but deletion of this 3.3-kb macrosatellite element might affect the...

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Detalhes bibliográficos
Main Authors: Ottaviani, Alexandre, Rival-Gervier, Sylvie, Boussouar, Amina, Foerster, Andrea M., Rondier, Delphine, Sacconi, Sabrina, Desnuelle, Claude, Gilson, Eric, Magdinier, Frédérique
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2639723/
https://ncbi.nlm.nih.gov/pubmed/19247430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000394
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