Pathology is alleviated by doxycycline in a laminin-α2-null model of congenital muscular dystrophy

OBJECTIVE: Congenital muscular dystrophy type 1A (MDC1A) is an autosomal recessive disease that is caused by loss-of-function mutations in the laminin-α2 gene and results in motor nerve and skeletal muscle dysfunction. In a previous study, we used genetic modifications to show that inappropriate ind...

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Hlavní autoři: Girgenrath, Mahasweta, Beermann, Mary Lou, Vishnudas, Vivek K., Homma, Sachiko, Miller, Jeffrey Boone
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2639627/
https://ncbi.nlm.nih.gov/pubmed/19086074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.21523
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