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Synthesis of H-bonding probes of α7 nAChR agonist selectivity

The α7 subtype of the nicotinic acetylcholine receptor (nAChR) is the target of studies aimed at identifying features that will lead to the development of selective therapeutics. Five arylidine anabaseines, three with pyridine rings and two with the pyrrole rings, were synthesized in 35 –65% yield v...

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Bibliografiske detaljer
Main Authors: Wang, Jingyi, Papke, Roger L., Horenstein, Nicole A.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2639621/
https://ncbi.nlm.nih.gov/pubmed/19081250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.11.044
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