A Cohort Study of Tumoral LINE-1 Hypomethylation and Prognosis in Colon Cancer

Genome-wide DNA hypomethylation plays has an important role in genomic instability and colorectal carcinogenesis. However, the relationship between cellular DNA methylation level and patient outcome remains uncertain. Using 643 colon cancers in two independent prospective cohorts, we quantified DNA...

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Bibliographic Details
Main Authors: Ogino, Shuji, Nosho, Katsuhiko, Kirkner, Gregory J., Kawasaki, Takako, Chan, Andrew T., Schernhammer, Eva S., Giovannucci, Edward L., Fuchs, Charles S.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
Subjects:
Brief Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2639290/
https://ncbi.nlm.nih.gov/pubmed/19033568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djn359
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