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Base excision repair of oxidative DNA damage and association with cancer and aging
Aging has been associated with damage accumulation in the genome and with increased cancer incidence. Reactive oxygen species (ROS) are produced from endogenous sources, most notably the oxidative metabolism in the mitochondria, and from exogenous sources, such as ionizing radiation. ROS attack DNA...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2639036/ https://ncbi.nlm.nih.gov/pubmed/18978338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgn250 |
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