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Charge Carrier Field Emission Determines the Number of Charges on Native State Proteins in Electrospray Ionization

Although multiple charging in electrospray ionization (ESI) is essential to protein mass spectrometry, the underlying mechanism of multiple charging has not been explicated. Here, we present a new theory to describe ESI of native-state proteins and predict the number of excess charges on proteins in...

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Detalhes bibliográficos
Main Authors: Hogan, Christopher J., Carroll, James A., Rohrs, Henry W., Biswas, Pratim, Gross, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2638767/
https://ncbi.nlm.nih.gov/pubmed/18461930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja801280c
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