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The disruptive effects of the CB(1) receptor antagonist rimonabant on extinction learning in mice are task-specific

RATIONALE: Disruption of CB(1) receptor signaling through the use of CB(1) (-/-) mice or the CB(1) receptor antagonist rimonabant (SR141716) has been demonstrated to impair extinction of learned responses in conditioned fear and Morris water maze tasks. In contrast, CB(1) (-/-) mice exhibited normal...

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Autori principali: Niyuhire, Floride, Varvel, Stephen A., Thorpe, Andrew J., Stokes, Rene J., Wiley, Jenny L., Lichtman, Aron H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2638087/
https://ncbi.nlm.nih.gov/pubmed/17211653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-006-0650-6
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