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3-Substituted Pyrazole Analogs of the Cannabinoid Type 1 (CB(1)) Receptor Antagonist Rimonabant: Cannabinoid Agonist-Like Effects in Mice via Non-CB(1), Non-CB(2) Mechanism

The prototypic cannabinoid type 1 (CB(1)) receptor antagonist/inverse agonist, rimonabant, is comprised of a pyrazole core surrounded by a carboxyamide with terminal piperidine group (3-substituent), a 2,4-dichlorophenyl group (1-substituent), a 4-chlorophenyl group (5-substituent), and a methyl gro...

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Библиографические подробности
Главные авторы: Wiley, Jenny L., Selley, Dana E., Wang, Pinglang, Kottani, Rudresha, Gadthula, Srinivas, Mahadeven, Anu
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2012
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263966/
https://ncbi.nlm.nih.gov/pubmed/22085649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.187815
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