Thymidylate synthase, dihydropyrimidine dehydrogenase, ERCC1, and thymidine phosphorylase gene expression in primary and metastatic gastrointestinal adenocarcinoma tissue in patients treated on a phase I trial of oxaliplatin and capecitabine

BACKGROUND: Over-expression of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) in tumor tissue is associated with insensitivity to 5-fluorouracil (5-FU). Over-expression of ERCC1 correlates with insensitivity to oxaliplatin (OX) therapy, while high thymidine phosphorylase (TP) le...

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Detalhes bibliográficos
Main Authors: Uchida, Kazumi, Danenberg, Peter V, Danenberg, Kathleen D, Grem, Jean L
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637882/
https://ncbi.nlm.nih.gov/pubmed/19105824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-386
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