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The antioxidant function of the p53 tumor suppressor
It is widely accepted that the p53 tumor suppressor restricts abnormal cells by induction of growth arrest, or by triggering apoptosis. Here we show that in addition p53 protects the genome from oxidation by reactive oxygen species (ROS), a major cause for DNA damage and genetic instability. In the...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2637821/ https://ncbi.nlm.nih.gov/pubmed/16286925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1320 |
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