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Tumor suppressor p53 stole the AKT in hypoxia

The presence of hypoxia within a tumor is associated with poor clinical outcome, which is often exacerbated by loss of the tumor suppressor p53. In the presence of functional p53, hypoxic conditions promote apoptosis; however, the p53-dependent genes that mediate this process are not well understood...

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Bibliografski detalji
Izdano u:J Clin Invest
Glavni autori: Yun, Zhong, Glazer, Peter M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497769/
https://ncbi.nlm.nih.gov/pubmed/25961449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82058
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