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Soluble Epoxide Hydrolase Inhibitors Reduce the Development of Atherosclerosis in Apolipoprotein E-Knockout Mouse Model

In order to determine whether sEH inhibitors influence atherosclerotic lesion formation, we utilized an established murine model of accelerated atherogenesis, ApoE knockout (−/−) mice. The sEH inhibitor, 1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea (AEPU) was delivered in drinking water. Al...

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Detalhes bibliográficos
Main Authors: Ulu, Arzu, Davis, Benjamin B., Tsai, Hsing-Ju, Kim, In-Hae, Morisseau, Christophe, Inceoglu, Bora, Fiehn, Oliver, Hammock, Bruce D., Weiss, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637359/
https://ncbi.nlm.nih.gov/pubmed/18791465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0b013e318185fa3c
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