Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways

During inflammation, a large amount of arachidonic acid (AA) is released into the cellular milieu and cyclooxygenase enzymes convert this AA to prostaglandins that in turn sensitize pain pathways. However, AA is also converted to natural epoxyeicosatrienoic acids (EETs) by cytochrome P450 enzymes. E...

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Detaylı Bibliyografya
Asıl Yazarlar: Inceoglu, Bora, Jinks, Steven L., Ulu, Arzu, Hegedus, Christine M., Georgi, Katrin, Schmelzer, Kara R., Wagner, Karen, Jones, Paul D., Morisseau, Christophe, Hammock, Bruce D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2008
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596245/
https://ncbi.nlm.nih.gov/pubmed/19028872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809765105
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