Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways

During inflammation, a large amount of arachidonic acid (AA) is released into the cellular milieu and cyclooxygenase enzymes convert this AA to prostaglandins that in turn sensitize pain pathways. However, AA is also converted to natural epoxyeicosatrienoic acids (EETs) by cytochrome P450 enzymes. E...

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Main Authors: Inceoglu, Bora, Jinks, Steven L., Ulu, Arzu, Hegedus, Christine M., Georgi, Katrin, Schmelzer, Kara R., Wagner, Karen, Jones, Paul D., Morisseau, Christophe, Hammock, Bruce D.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2008
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596245/
https://ncbi.nlm.nih.gov/pubmed/19028872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809765105
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