In vitro–differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations

The morbidity and mortality associated with graft-host-disease (GVHD) is a significant obstacle to the greater use of allogeneic stem cell transplantation. Donor T cells that predominantly differentiate into TH1/Tc1 T cells and generate pro-inflammatory cytokines such as interferon-γ (IFN-γ) mediate...

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Bibliographic Details
Main Authors: Carlson, Michael J., West, Michelle L., Coghill, James M., Panoskaltsis-Mortari, Angela, Blazar, Bruce R., Serody, Jonathan S.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2009
Subjects:
Transplantation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637199/
https://ncbi.nlm.nih.gov/pubmed/18957685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-06-162420
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