Increased extracellular pressure enhances cancer cell integrin-binding affinity through phosphorylation of β(1)-integrin at threonine 788/789

Increased extracellular pressure stimulates β(1)-integrin-dependent cancer cell adhesion. We asked whether pressure-induced adhesion is mediated by changes in β(1)-integrin binding affinity or avidity and whether these changes are phosphorylation dependent. We evaluated integrin affinity and cluster...

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Bibliografiske detaljer
Main Authors: Craig, David H., Gayer, Christopher P., Schaubert, Keri L., Wei, Yanzhang, Li, Jinhua, Laouar, Yasmina, Basson, Marc D.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2009
Fag:
Extracellular Matrix, Cell Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637001/
https://ncbi.nlm.nih.gov/pubmed/19005162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00355.2008
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