Identification of Integrin β Subunit Mutations That Alter Affinity for Extracellular Matrix Ligand

We examined over 50 mutations in the Drosophila βPS integrin subunit that alter integrin function in situ for their ability to bind a soluble monovalent ligand, TWOW-1. Surprisingly, very few of the mutations, which were selected for conditional lethality in the fly, reduce the ligand binding abilit...

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Bibliographic Details
Main Authors: Kendall, Timmy, Mukai, Leona, Jannuzi, Alison L., Bunch, Thomas A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162457/
https://ncbi.nlm.nih.gov/pubmed/21757698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.254797
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