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Expression of active p21-activated kinase-1 induces Ca(2+) flux modification with altered regulatory protein phosphorylation in cardiac myocytes
p21-Activated kinase-1 (Pak1) is a serine-threonine kinase that associates with and activates protein phosphatase 2A in adult ventricular myocytes and, thereby, induces increased Ca(2+) sensitivity of skinned-fiber tension development mediated by dephosphorylation of myofilament proteins (Ke Y, Wang...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Physiological Society
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2636994/ https://ncbi.nlm.nih.gov/pubmed/18923061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00012.2008 |
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