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Expression of active p21-activated kinase-1 induces Ca(2+) flux modification with altered regulatory protein phosphorylation in cardiac myocytes

p21-Activated kinase-1 (Pak1) is a serine-threonine kinase that associates with and activates protein phosphatase 2A in adult ventricular myocytes and, thereby, induces increased Ca(2+) sensitivity of skinned-fiber tension development mediated by dephosphorylation of myofilament proteins (Ke Y, Wang...

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Detalhes bibliográficos
Main Authors: Sheehan, Katherine A., Ke, Yunbo, Wolska, Beata M., Solaro, R. John
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636994/
https://ncbi.nlm.nih.gov/pubmed/18923061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00012.2008
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