Upregulation of Phagocyte-Derived Catecholamines Augments the Acute Inflammatory Response

Following our recent report that phagocytic cells (neutrophils, PMNs, and macrophages) are newly discovered sources of catecholamines, we now show that both epinephrine and norepinephrine directly activate NFκB in macrophages, causing enhanced release of proinflammatory cytokines (TNFα, IL-1β, IL-6)...

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Main Authors: Flierl, Michael A., Rittirsch, Daniel, Nadeau, Brian A., Sarma, J. Vidya, Day, Danielle E., Lentsch, Alex B., Huber-Lang, Markus S., Ward, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2009
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636885/
https://ncbi.nlm.nih.gov/pubmed/19212441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004414
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