Upregulation of Phagocyte-Derived Catecholamines Augments the Acute Inflammatory Response

Following our recent report that phagocytic cells (neutrophils, PMNs, and macrophages) are newly discovered sources of catecholamines, we now show that both epinephrine and norepinephrine directly activate NFκB in macrophages, causing enhanced release of proinflammatory cytokines (TNFα, IL-1β, IL-6)...

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Detalhes bibliográficos
Main Authors: Flierl, Michael A., Rittirsch, Daniel, Nadeau, Brian A., Sarma, J. Vidya, Day, Danielle E., Lentsch, Alex B., Huber-Lang, Markus S., Ward, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636885/
https://ncbi.nlm.nih.gov/pubmed/19212441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004414
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