Upregulation of Phagocyte-Derived Catecholamines Augments the Acute Inflammatory Response

Following our recent report that phagocytic cells (neutrophils, PMNs, and macrophages) are newly discovered sources of catecholamines, we now show that both epinephrine and norepinephrine directly activate NFκB in macrophages, causing enhanced release of proinflammatory cytokines (TNFα, IL-1β, IL-6)...

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Главные авторы: Flierl, Michael A., Rittirsch, Daniel, Nadeau, Brian A., Sarma, J. Vidya, Day, Danielle E., Lentsch, Alex B., Huber-Lang, Markus S., Ward, Peter A.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2009
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636885/
https://ncbi.nlm.nih.gov/pubmed/19212441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004414
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