Comparison of the enantiomers of (±)-doxanthrine, a high efficacy full dopamine D(1) receptor agonist, and a reversal of enantioselectivity at D(1) versus alpha(2C) adrenergic receptors

Parkinson’s disease is a neurodegenerative condition involving the death of dopaminergic neurons in the substantia nigra. Dopamine D(1) receptor agonists are potential alternative treatments to current therapies that employ L-DOPA, a dopamine precursor. We evaluated the pharmacological profiles of t...

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Main Authors: Przybyla, Julie A., Cueva, Juan P., Chemel, Benjamin R., Joseph Hsu, K., Riese, David J., McCorvy, John D., Chester, Julia A., Nichols, David E., Watts, Val J.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636714/
https://ncbi.nlm.nih.gov/pubmed/19028082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.euroneuro.2008.10.002
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