Transgenic Mice Expressing Dominant Negative Bright Exhibit Defects in B1 B Cells

The transcription factor Bright up-regulates immunoglobulin heavy chain production from select variable region promoters and requires Bright dimerization, Bruton’s tyrosine kinase (Btk) and the Btk substrate, TFII-I for this activity. Defects in Btk cause X-linked immunodeficiency disease in mice an...

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Bibliographic Details
Main Authors: Nixon, Jamee C., Ferrell, Scott, Miner, Cathrine, Oldham, Athenia L., Hochgeschwender, Ute, Webb, Carol F.
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636627/
https://ncbi.nlm.nih.gov/pubmed/18981111
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