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Twinned crystals of adeno-associated virus serotype 3b prove suitable for structural studies

Adeno-associated viruses (AAVs) are leading candidate vectors for gene-therapy applications. The AAV-3b capsid is closely related to the well characterized AAV-2 capsid (87% identity), but sequence and presumably structural differences lead to distinct cell-entry and immune-recognition properties. I...

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Detalhes bibliográficos
Main Authors: Lerch, Thomas F., Xie, Qing, Ongley, Heather M., Hare, Joan, Chapman, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635862/
https://ncbi.nlm.nih.gov/pubmed/19194015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309109000372
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