Targeted disruption of the Cl(−)/HCO(3)(−) exchanger Ae2 results in osteopetrosis in mice

Osteoclasts are multinucleated bone-resorbing cells responsible for constant remodeling of bone tissue and for maintaining calcium homeostasis. The osteoclast creates an enclosed space, a lacuna, between their ruffled border membrane and the mineralized bone. They extrude H(+) and Cl(−) into these l...

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Autori principali: Josephsen, Kaj, Praetorius, Jeppe, Frische, Sebastian, Gawenis, Lara R., Kwon, Tae-Hwan, Agre, Peter, Nielsen, Søren, Fejerskov, Ole
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635809/
https://ncbi.nlm.nih.gov/pubmed/19164575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811682106
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